Thursday, 9 Jul 2020

The key to longevity identified – Naturopathy naturopathy specialist portal

Increased life expectancy due to higher Humanin-values?

A special Protein seems to have a major impact on the health and longevity of animals and humans. This discovery could enable the treatment of a variety of age-related diseases.

In the case of an investigation under the auspices of the Leonard Davis School of Gerontology, University of Southern California, it was found that the peptide Humanin seems to have a significant impact on the life expectancy of humans and animals. The results were published in the English journal “Aging”.

Study included people and animals


For the study, a peptide named Humanin was investigated, which is encoded in the small genome of the mitochondria. Values of Humanin were analyzed in several animal species, including worms and mice, as well as in people, including individuals with Alzheimer’s and 18 children of a hundred years.

Humani mirror associated with life expectancy

From experiments in laboratory animals to measurements on humans, the research shows how higher humani mirror hanging in the body, with longer lifespan and better health. This is also associated with a lower risk for diseases such as Alzheimer’s disease, report the researchers.

Humanin may help to prevent age-related diseases


Humanin has long been known that it contributes to the prevention of many age-related diseases. The current study shows for the first time, that Humanin can also extend the life span, report the researchers.

Humanin is the key to the regulation of life span?

The results of the study illustrate the potential of Humanin and other mitochondrial proteins for the treatment of age-related diseases. They also suggest that Humanin could be a age of mitochondrial signal mechanism, which is key for the regulation of the health and life span of the body, explains the research group.

Humanin decreases normally with age

Humanin-values in the case of many species with age. In the new study, the researchers observed higher Humanin-values in organisms that are predisposed to a long life, including the naked mole rat. The naked mole rat learns during his 30-year life span, only a very slow decline in the body circulating Humanin levels.

The massive decline of Humanin in the course of life

In contrast, mice suffer in the first 18 months of life, a massive 40% decrease in the number of Humanin, and primates such as rhesus monkeys seem to have a similar dramatic decline in the Humanins between the ages of 19 and 25 years to go through, the Team reported.

Children of Centenarians had a higher humanitarian level

In humans, the researchers observed the phenomenon of higher and continuing of humani mirror 18 children of Centenarians compared with a control group of 19 children of a hundred years. Children of a hundred years, to achieve statistically more likely to be a high age.

What is an increase in the humani mirror caused?

In the case of some species, including worms and mice, it was sufficient to alter their genes so that they produce higher amounts of Humanin in your body, in order to extend the life span significantly. But these long-lived animals had fewer offspring. Researchers have observed a similar pattern in the case of long-lived people.

Compromise between longevity and reproduction?

This compromise between longevity and reproduction is probably the result of an evolutionarily conserved balance between the use of energy for the production of more offspring, or of the use of energy to maintain the organism for future reproductive efforts, explain the researchers.

Effect on disease?

Higher humanitarian values are not only associated with a prolonged service life. Lower values can increase the risk of disease and the resistance to toxic exposures reduce. The researchers analysed samples of spinal fluid of a small number of Alzheimer’s patients and control subjects without dementia. They found that the Humanin-values in the case of Alzheimer’s patients is much lower.

Effect of the humani mirror on mitochondrial DNA

In umbilical cord blood samples of newborns correlated high humani mirror with a high number of copies of mitochondrial DNA (mtDNA) or the number of copies of the mitochondrial genome in each cell. Humanin levels are Vice versa correlated with a decrease in the copy number of mitochondrial DNA (mtDNA), the kidneys in a number of different diseases, such as cancer, and cardiovascular diseases has been associated, says the research group.

Humanin has potential for the treatment of age-related diseases

The new, wide-ranging study underlines the importance of Humanin as a potentially powerful Regulator of the life span and health. Humanin could be useful for the treatment of a variety of age-related diseases, the hope of the researchers. (as)

Authors and source of information