Experts reframe ‘clinical meaningfulness’ in Alzheimer’s
- Simply slowing the progression of the disease—rather than halting it, which may come eventually—has measurable and meaningful benefits for patients and their families, especially in early Alzheimer’s when cognition and memory are mostly intact.
- A statistically significant benefit in an 18-month clinical trial may signify and lead to an even more meaningful change when projected out over succeeding years.
- It is unlikely that any single intervention on dementia-related brain changes will have a large clinical effect on its own. For greater impact, combination therapies will be needed, just as we treat elevated blood pressure and cancer today.
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