Friday, 9 Dec 2022

Antibiotic-resistant bacteria with the Alzheimer’s drug fight

Alzheimer’s drug against antibiotic resistance

Recently, the world health organization (WHO) pointed out that the resistance to antibiotics worldwide is extremely increasing. This poses great threats to global health. However, researchers from Australia have found maybe a solution for the Problem.

Dangerous increase in antibiotic resistance

The increase in antibiotic resistance in health care represents a growing challenge. If the Problem is not brought soon under control, threatens researchers, according to a nightmare scenario. According to an older study by the Berlin Charité, there could be up to 2050, of around ten million Deaths due to multi-resistant germs. In the past few years, more and more governments and experts have announced that the fight against antibiotic resistance increase. Australian researchers have now gained new insights about how the Problem could possibly be solved.

The drug was originally intended for the treatment of Alzheimer’s disease

As the Australian-new Zealand Association of higher education institutions / Institut Ranke-Heinemann reported in a communication that could be dangerous, antibiotic-resistant bacteria soon with a drug, which was originally developed for Alzheimer’s disease.

This is the result of a joint research project between the Griffith University and the University of Queensland in Brisbane.

The results of the experts were published in the journal “mBio”.

According to the figures, the researchers have considered mainly the anti-bacterial properties of PBT2.

This is a metal TRANS-porter of drug, which was originally intended for the treatment of Alzheimer’s disease and Huntington’s disease.

One of the greatest threats to Health worldwide

According to Professor Mark von Itzstein, Director of the Institute for Glycomics at Griffith University, this exciting news. Especially because resistance to antibiotics is to be in the Moment, one of the greatest threats to Health worldwide.

“Over the past 30 years, many bacteria have developed resistance against a range of antibiotic drugs,” explained the researchers in a press release.

“This has led to the current antibiotic treatment is ineffective and there is in consequence a growing number of cases of death by infectious diseases in Australia,” said von Itzstein.

“If no new solutions are discovered, it is estimated that by 2050, antimicrobial, resistant bacteria for about 10 million deaths worldwide. Now we have found another weapon, which helps us to save millions of lives!“

Effective means for the treatment of infectious diseases

Professor Mark Walker from the School of Chemistry and Molecular Biosciences the University of Queensland does not perform that also, if PBT2 makes it to the market for these diseases, it has proven to be, nevertheless, of great utility.

“This particular drug has passed the phase 1 and 2 clinical studies for Alzheimer’s and Huntington’s disease. In addition, it has been shown that it was well tolerated by human patients,“ he said in a message.

“PBT2 has been developed to prevent the interaction between metals and human cells. It was hoped that it would reduce the deposition of heavy metals in the brain,“ says Walker.

“With this in mind, and the Knowledge that the prevention of metal deposits for bacteria is non-toxic, we have considered more precisely, what is the effect of PBT2 has against a range of antibiotic-resistant bacteria.”

The results suggest that this drug has the capacity to combat antibiotic-resistant bacteria.

“The use of PBT2 as a cure for antibiotic-resistance is a whole new strategy,” said Professor Walker.

“Possibly we are able to make resistance to antibiotics inasmuch as undo, so that antibiotics be an effective agent in the treatment of infectious diseases.” (ad)