A collaboration between Merck & Co and Codexis, Inc. has resulted in the development of a nine-enzyme, chain-reaction approach for making the HIV drug islatravir. In their paper published in the journal Science, the group describes the inspiration for their work and how well the final product turned out. Elaine O’Reilly and James Ryan with […]
Aspirin use three or more times per week is associated with reductions in all-cause, any cancer, gastrointestinal cancer, and colorectal cancer (CRC) mortality among older adults, according to a study published online Dec. 4 in JAMA Network Open. Holli A. Loomans-Kropp, Ph.D., M.P.H., from the National Cancer Institute in Rockville, Maryland, and colleagues examined the […]
In a paper published in today’s online issue of the Journal of Alzheimer’s Disease, TauRx has reported unexpected results of a pharmacokinetic analysis of the relationship between treatment dose, blood levels and pharmacological activity of the drug hydromethylthionine on the brain in over 1,000 patients with mild-to-moderate Alzheimer’s disease. These results showed that, even at […]
New migraine medications block αCGRP, a neuropeptide which causes vasodilation, for example in the meninges. The very same peptide, which is formed in the muscles during physical activity, protects the heart—which is vital for people with chronic high blood pressure. The innovative migraine prophylaxis could endanger these people, as researchers at the University of Zurich […]
The rescheduling of all codeine-containing products as prescription-only medications from 1 February 2018 has been associated with a 53 percent drop in codeine-related presentations at a major Brisbane hospital’s toxicology unit, according to the authors of research published online today by the Medical Journal of Australia. A total of 2235 patients presented to the Princess […]
A new curated library, activated today, provides a centralized toolkit for policymakers, patients and health care professionals working to address the nation’s opioid epidemic. The epidemic kills tens of thousands of Americans annually, yet decision-makers report that they’ve struggled to make sense of an overwhelming and often-bewildering array of data. It can be hard to […]
Every day, more than 100 Americans lose their lives to the opioid crisis, and researchers from across the nation are racing to find solutions. One of the latest strategies—a cascade of care model for the State of Rhode Island—was developed collaboratively by a diverse group of stakeholders, including experts from Brown University, state agency leaders […]
Researchers from the Oregon Research Institute (ORI) and Florida Atlantic University (FAU) are the first to demonstrate statistically significant links between self-reported regular use of prescription drugs for pain and/or sleep, and longitudinal risk of frailty in adults ages 65 and older. Frailty consists of deficits in a variety of functional measures, and is a […]
Grape stems are discarded en masse during the production of wine. We love and produce a lot of wine in Nagano prefecture, and have been hoping to find a positive use for the previously discarded grape stems. Scientists at Shinshu University studied compounds within grape stem extracts and found significant anti-cancer activity on tumor cells. […]
Despite harm reduction being one of the three pillars of the National Drug Strategy, Australian governments are shying away from pill-testing despite evidence suggesting it provides a useful tool for both direct harm reduction, as well as indirect harm reduction through the increased education of a hard-to-reach group of drug users, according to the authors […]
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One of the emerging questions about the coronavirus that scientists are working to understand is why developing countries are showing markedly lower rates of mortality in COVID-19 cases than expected. Research by Assistant Professor Luis Escobar of the College of Natural Resources and Environment and two colleagues at the National Institutes of Health suggests that […]
