Friday, 27 Nov 2020

Medications

CEPI Extends Partnership with Clover Biopharmaceuticals to Fund COVID-19 Vaccine Candidate Through Global Phase 2/3 Study to Licensure

OSLO, Norway and CHENGDU, China. 03 November,2020— CEPI, the Coalition for Epidemic Preparedness Innovations, today announced that it will fund the development of the protein-based  S-Trimer COVID-19 vaccine candidate by Sichuan Clover Biopharmaceuticals, Inc (China) (“Clover”) through a global pivotal Phase 2/3 efficacy clinical trial and to licensure in China and globally, if the vaccine is […]

FDA Approves Sesquient

FDA Approves Sesquient (fosphenytoin sodium) for the Treatment of Status Epilepticus in Adult and Pediatric Patients PAOLI, Pa., — (BUSINESS WIRE) — November 9, 2020 – Sedor Pharmaceuticals, LLC (Sedor) today announced that the U.S. Food and Drug Administration (FDA) has approved Sesquient (fosphenytoin sodium for injection) for the treatment of status epilepticus in adult […]

Statement—NIH-Sponsored ACTIV-3 Trial Closes LY-CoV555 Sub-Study

October 26, 2020 — The ACTIV-3 clinical trial evaluating the investigational monoclonal antibody LY-CoV555 in hospitalized patients with COVID-19 will not enroll more participants into this sub-study following a recommendation from the independent Data and Safety Monitoring Board (DSMB). The trial is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of […]

Harmony Biosciences Receives FDA Approval for Expanded Use of Wakix (pitolisant) for the Treatment Of Cataplexy in Adult Patients with Narcolepsy

PLYMOUTH MEETING, PA and CHICAGO, IL, October 13, 2020 — Harmony Biosciences Holdings, Inc. (“Harmony”) (Nasdaq: HRMY), a pharmaceutical company dedicated to developing and commercializing innovative therapies for patients living with rare neurological disorders who have unmet medical needs, today announced the U.S. Food and Drug Administration (FDA) has approved Wakix (pitolisant) for the treatment […]

Sanofi and Translate Bio mRNA COVID-19 Vaccine Candidate Induced High Antibody Levels in Preclinical Studies

PARIS and LEXINGTON, MASS. – October 15, 2020 – Sanofi Pasteur, the vaccines global business unit of Sanofi, and Translate Bio (NASDAQ: TBIO), a clinical-stage messenger RNA (mRNA) therapeutics company, today announced the preclinical results for MRT5500, a mRNA-based vaccine candidate against SARS-CoV-2, the virus that causes COVID-19 disease. Preclinical evaluation of MRT5500, importantly, demonstrated a […]

Baricitinib in Combination with Remdesivir Reduces Time to Recovery in Hospitalized Patients

INDIANAPOLIS, Sept. 14, 2020 /PRNewswire/ — Eli Lilly and Company (NYSE: LLY) and Incyte (NASDAQ: INCY) announced today initial data emerging from the Adaptive COVID-19 Treatment Trial (ACTT-2) sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). ACTT-2 included more than 1,000 patients and began on May 8 to assess […]

A nine-enzyme chain-reaction approach for making the HIV drug islatravir

A collaboration between Merck & Co and Codexis, Inc. has resulted in the development of a nine-enzyme, chain-reaction approach for making the HIV drug islatravir. In their paper published in the journal Science, the group describes the inspiration for their work and how well the final product turned out. Elaine O’Reilly and James Ryan with […]

Aspirin use may reduce cancer, all-cause mortality in seniors

Aspirin use three or more times per week is associated with reductions in all-cause, any cancer, gastrointestinal cancer, and colorectal cancer (CRC) mortality among older adults, according to a study published online Dec. 4 in JAMA Network Open. Holli A. Loomans-Kropp, Ph.D., M.P.H., from the National Cancer Institute in Rockville, Maryland, and colleagues examined the […]

Study: Minimum dose of hydromethylthionine could slow cognitive decline in mild-to-moderate Alzheimer’s

In a paper published in today’s online issue of the Journal of Alzheimer’s Disease, TauRx has reported unexpected results of a pharmacokinetic analysis of the relationship between treatment dose, blood levels and pharmacological activity of the drug hydromethylthionine on the brain in over 1,000 patients with mild-to-moderate Alzheimer’s disease. These results showed that, even at […]

New migraine medications could endanger patients with high blood pressure

New migraine medications block αCGRP, a neuropeptide which causes vasodilation, for example in the meninges. The very same peptide, which is formed in the muscles during physical activity, protects the heart—which is vital for people with chronic high blood pressure. The innovative migraine prophylaxis could endanger these people, as researchers at the University of Zurich […]

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