Friday, 27 Nov 2020

Health Problems


sutimlimab FDA Issues Complete Response Letter for Sutimlimab, an Investigational Treatment for Hemolysis in Adults with Cold Agglutinin Disease PARIS – November 13, 2020 – The U.S. Food and Drug Administration issued a Complete Response Letter (CRL) regarding the Biologics License Application (BLA) for sutimlimab, an investigational monoclonal antibody for the treatment of hemolysis in adults […]


vosoritide FDA Accepts BioMarin’s New Drug Application for Vosoritide to Treat Children with Achondroplasia SAN RAFAEL, Calif., Nov. 2, 2020 /PRNewswire/ — BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) today announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) for vosoritide, an investigational, once daily injection analog of C-type Natriuretic Peptide (CNP) […]

Racial differences seen with hypertrophic cardiomyopathy

(HealthDay)—Racial differences in disease expression and adverse clinical outcomes exist between black and white patients with hypertrophic cardiomyopathy, according to a study published online Dec. 4 in JAMA Cardiology. Lauren A. Eberly, M.D., from Brigham and Women’s Hospital in Boston, and colleagues assessed data from the Sarcomeric Human Cardiomyopathy Registry (1989 through 2018) to evaluate […]

NFL coaches’ drive for success can be hard on their hearts

You’re not likely to find any studies linking heart disease and NFL coaches—just a long list of familiar names. Among them: Mike Ditka of the Chicago Bears, who had heart attacks in 1988 and 2018. Bill Parcells of the New York Giants and other teams, who needed bypass surgery in 1992. Dennis Green of the […]

Imaging of conjunctival goblet cells helps diagnosis of dry eyes

Goblet cells are epithelial cells that produce mucins and disperse tears which help the surface of eyes maintain their wet environment. Goblet cells are closely related to autoimmune diseases including dry eyes and chemical burns. Therefore, it is very important to examine the status of goblet cells to better understand and diagnose ocular disease. Professor […]

Vaccine group announces creation of Ebola vaccine stockpile

The vaccine alliance GAVI announced Thursday it would invest $178 million to create a global stockpile of about 500,000 Ebola vaccines, a decision that health officials say could help prevent future outbreaks from spiraling out of control. The public-private partnership includes the World Health Organization, UNICEF, the Bill & Melinda Gates Foundation and the World […]

Molecular bodyguards against Parkinson’s disease

Chaperone proteins in human cells dynamically interact with the protein α-Synuclein, which is strongly associated with Parkinson’s disease. A disturbed relationship to these “bodyguards” leads to cell damage and the formation of Lewy bodies typical for Parkinson’s disease. The findings by researchers from the University of Basel’s Biozentrum have been published in Nature. Parkinson’s disease […]

How a protein in your brain could protect against Alzheimer’s disease

New research has found that the most common version of a protein called CD33 plays a crucial role in regulating white blood cells in the human brain, which could have important implications in the fight against Alzheimer’s disease. The study builds on previous research that had identified the protein as a factor that may decrease […]

New remote-controlled ‘smart’ platform helps in cardiovascular disease treatment

According to the World Health Organization, cardiovascular (CV) disease has become the leading cause of death worldwide. However, vascular regeneration is a promising treatment for cardiovascular disease. Remodeling the endothelium—i.e., forming a confluent vascular endothelial cell monolayer on the lumen—plays a vital role in this process. Rapid endothelialization poses challenges, however, when using existing synthetic […]

Study suggests new strategies against bone metastases from prostate cancer

When prostate cancer spreads, it most often spreads to bone. And while the 5-year survival rate for prostate cancer that has not spread is nearly 100 percent, once the disease reaches bone, the 5-year survival rate is only 29 percent. Now a University of Colorado Cancer Center study published in the Journal for Immunotherapy of […]

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