Thursday, 25 Apr 2019

New discovery in how mammals sense the cold could lead to new pain relief drugs

Researchers at UCL have shown for the first time that mammals detect different intensities of cold using distinct sensory neuron systems, a finding which could lead to the development of new drugs to treat cold pain. The study on mice, published in Proceedings of the National Academy of Sciences, set out to understand more about […]

Socioeconomic deprivation increases risk of developing chronic kidney disease in England

The George Institute for Global Health at the University of Oxford investigated whether there was an association between socioeconomic deprivation (measured using the English Index of Multiple Deprivation combining income, employment, health and disability, education, skills and training, barriers to housing and services, crime, and living environment, into a single score by geographical area) and […]

Despite health warnings, Americans still sit too much

Most Americans continue to sit for prolonged periods despite public health messages that such inactivity increases the risk of obesity, diabetes, heart disease and certain cancers, according to a major new study led by researchers at Washington University School of Medicine in St. Louis. The research team analyzed surveys of 51,000 people from 2001 to […]

Army publishes new findings to support soldier training

Researchers recently demonstrated that people’s attitudes about avoiding negative outcomes versus achieving positive outcomes is related to how their performance changes in response to gamified feedback during simulation-based training exercises. The research took place at the U.S. Army Combat Capabilities Development Command’s Army Research Laboratory, the Army’s corporate research laboratory known as ARL, at its […]

Atrial fibrillation is now the leading cause of cardiovascular hospitalisation

Atrial fibrillation has overtaken heart failure and heart attacks as the leading cause of cardiovascular hospitalisation, a South Australian study has found. Researchers analysed data collected over two decades by the Australian Institute of Health and Welfare to establish the incidence and trends of common cardiovascular conditions between 1993 and 2013. Published recently in the […]

Hole-forming protein may suppress tumor growth

Sometimes cells need to die. The process of cell death is encoded within the genome of all higher organisms to kill off cancerous cells, and as a normal part of development to shape a mass of embryonic cells into the organism it will become. Now Jefferson researchers show a gene called gasdermin E, which is […]

Risk of congenital Zika syndrome greater than previously thought

Zika virus infection during pregnancy was first linked to birth defects during the outbreak in the Americas in 2015 and 2016; however, the Zika virus was discovered decades ago. Why then were adverse outcomes during pregnancy only recently recognized when the Zika virus has been circulating in Africa and Asia for decades? A provocative explanation […]

The brain’s imperfect execution of mathematically optimal perception

Human perception is based on mathematically optimal principles, but the brain implements those principles imperfectly, suggests new research by Elina Stengård and Ronald van den Berg of the University of Uppsala, Sweden. They present their findings in PLOS Computational Biology. The human brain uses imprecise sensory inputs to determine truths about the surrounding environment. Previous […]

Lithium boosts muscle strength in mice with rare muscular dystrophy

Standing up from a chair, climbing stairs, brushing one’s hair – all can be a struggle for people with a rare form of muscular dystrophy that causes progressive weakness in the shoulders and hips. Over time, many such people lose the ability to walk or to lift their arms above their heads. This form of […]

RNA sequencing used to discover novel genes and pathways in celiac disease

Researchers at the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children (MGHfC) have discovered novel genes and pathways related to early stages in the development of celiac disease and the ongoing inflammation and comorbidities associated with the condition. The findings, published in PLOS One, include analyses of RNA sequences in duodenal biopsies […]